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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Allergy Clin Immunol. 2017 Feb 9;140(5):1404–1415.e9. doi: 10.1016/j.jaci.2016.12.972

Figure 1.

Figure 1

Maternal HDM exposure increases the severity of AHR and airway inflammation in HDM-exposed offspring. Pregnant female mice were exposed to HDM or PBS on days 0, 4 and 10 of pregnancy. Offspring of PBS- and HDM-exposed mothers were exposed to PBS or HDM at 6, 8 and 9 weeks of age and development of AHR was assessed (A). After sacrifice, BAL fluid was collected to assess (B) total BAL cellularity, and the number of (C) lymphocytes, (D) eosinophils, (E) neutrophils and (F) macrophages. Mean + SEM shown. Data represent 7 – 18 mice pooled from 4 experiments.