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BVL according to on-study disability worsening in (A) placebo-treated patients with and without 12- or 24-week confirmed disability worsening (CDW); (B) placebo- and teriflunomide 14 mg–treated patients with 12- or 24-week CDW; (C) placebo- and teriflunomide 14 mg–treated patients without 12- or 24-week CDW. BVL = brain volume loss; CI = confidence interval. *Relative change vs patients without CDW; **Relative change vs placebo.
