Table 2.
Pathologic features of the patients with breast carcinoma metastases to the head and neck
| Case | Site | Histologic type | Positive immunostains | Negative immunostains | Breast receptor studies in metastatic specimen |
|---|---|---|---|---|---|
| 1 | Bilateral palatine tonsils | Pagetoid carcinoma | CK7, GCDFP-15 | N/A | ER (−) |
| 2 | Paratracheal soft tissue | Ductal carcinoma | GATA3, panCK,AR | Synaptophysin | ER (+), PR unk, Her2 unk |
| 3 | Nasal cavity | Mucinous carcinoma | GATA3 | TTF-1, CDX2, mammaglobin, GCDFP-15 | ER (+), PR (−) |
| 4 | Mastoid sinus | Ductal carcinoma | CK7 | Synaptophysin, chromogranin | ER (+) |
| 5 | Mastoid sinus | Adenocarcinoma* | N/A | N/A | ER (+), PR (+) |
| 6 | Skin face | Lobular carcinoma | CK7 | Mammaglobin, P63, BerEP4 | ER (+),PR (+), Her-2 (−) |
| 7 | Skull base | Mucinous carcinoma | CK7 | CK20 | ER (+), PR (−), Her-2 (+) |
| 8 | Skull base | Carcinoma with lobular features | GATA3, AR, CK7 | GCDFP-15, synaptophysin, chromogranin, P40 | ER (+), PR (+), Her-2 (−) |
| 9 | Skull base/clivus | Ductal carcinoma | panCK, GATA3 | P40, S-100, PAX8, SOX10, TTF-1 | ER (+), PR (+), Her-2 (−) |
| 10 | Oral cavity | Ductal carcinoma | N/A | N/A | Her-2 (−) |
| 11 | Oral cavity | Pagetoid carcinoma | CK7 | GCDFP-15 | Her-2 (−) |
| 12 | Oral cavity | Lobular carcinoma | panCK, CK7 | CK20 | ER (+), PR (+), Her-2 unk |
| 13 | Orbital soft tissue | Lobular carcinoma | N/A | N/A | N/A |
| 14 | Orbital soft tissue/ethmoid and maxillary sinus | Ductal carcinoma | CK7 | CK20, BCA-225 | N/A |
| 15 | Orbital soft tissue | Lobular carcinoma | N/A | N/A | ER (+), PR (+), Her-2 (−) |
| 16 | Orbital soft tissue | Lobular carcinoma | CK7 | CK20 | ER (+), PR (−) |
| 17 | Orbital soft tissue | Lobular carcinoma | GATA3, panCK | CD45 | ER (+), PR weak (+), Her-2 (−) |
| 18 | Neck lymph node | Lobular carcinoma | N/A | GCDFP-15, synaptophysin, chromogranin | ER (+), PR (+), Her-2 (−) |
| 19 | Neck lymph node | Ductal carcinoma | N/A | N/A | N/A |
| 20 | Neck lymph node | Ductal carcinoma | Mammaglobin, CK7 | GCDFP-15, CK20 | ER (+), PR (−), Her-2 (+) |
| 21 | Neck lymph node | Ductal carcinoma | N/A | N/A | ER (+), PR (+), Her-2 (+) |
| 22 | Neck lymph node | Lobular carcinoma | Mammaglobin, GCDFP-15 (focal +), panCK | N/A | N/A |
| 23 | Neck lymph node | Ductal carcinoma | N/A | N/A | N/A |
| 24 | Neck lymph node | Ductal carcinoma | N/A | N/A | ER (+), PR (+), Her-2 (−) |
| 25 | Neck lymph node | Ductal carcinoma | GATA3 | TTF-1 | ER (+), PR (−), Her-2 (equiv) |
* Histologic type not further classified due to crush artifact
panCK pan cytokeratin, CK7 cytokeratin 7, CK20 cytokeratin 20, GCDFP-15 gross cystic disease fluid protein 15, ER estrogen receptor, PR progesterone receptor, unk unknown, equiv equivocal