Table 3.

Unusual pathologic features seen in breast metastases to the head and neck region

High proportion of lobular carcinoma amongst orbital soft tissue metastases

Skull base perineural carcinoma causing neurologic symptoms in the absence of a mass lesion

Pagetoid spread of metastatic tumor cells in oral and oropharyngeal mucosa

Prominent mucinous component in metastases despite little or no mucin production in primary lesion

Mucosal-based carcinoma with regional cervical adenopathy, mimicking a new primary head and neck lesion