Table 1.
Clinical and demographic information
| Patient | Age | Sex | Location | Diagnosis | p16 IHC | HPV RNA ISH |
|---|---|---|---|---|---|---|
| 1 | 70 | M | Maxillary sinus | ISP | – | – |
| 2 | 73 | M | Maxillary sinus | ISP | – | – |
| 3 | 74 | F | Maxillary sinus | ISP | – | – |
| Nasal cavity | ISP | – | – | |||
| 4 | 51 | F | Nasal cavity | ISP | – | – |
| Nasal cavity | ISP | – | – | |||
| 5 | 71 | M | Frontal sinus | ISP | – | – |
| Frontal sinus | ISP | – | – | |||
| Frontal sinus | ISP | – | – | |||
| 6 | 63 | M | Ethmoid sinus | ISP | – | – |
| 7 | 54 | M | Ethmoid sinus | ISP | – | – |
| 8 | 48 | M | Frontal sinus | ISP | – | – |
| Frontal sinus | ISP | – | – | |||
| Frontal sinus | ISP | – | – | |||
| 9 | 54 | F | Frontal sinus | ISP | – | – |
| 10 | 94 | M | Nasal cavity | ISP | – | – |
| 11 | 39 | F | Maxillary sinus | ISP | – | – |
| 12 | 64 | M | Frontal sinus | ISP | – | – |
| 13 | 75 | M | Nasal cavity | ISP | – | – |
| Maxillary sinus | ISP | – | – | |||
| 14 | 55 | M | Nasal cavity | ISP | – | – |
| 15 | 45 | F | Nasal cavity | ISP | – | – |
| 16 | 57 | M | Nasal cavity | ISP | – | – |
| 17 | 68 | M | Maxillary sinus | ISP | – | – |
| 18 | 28 | M | Nasal cavity | ISP | – | – |
| 19 | 61 | F | Sphenoid sinus | ISP | – | – |
| 20 | 53 | F | Maxillary sinus | ISP | – | – |
| 21 | 58 | M | Nasal cavity | ISP | – | – |
| 22 | 75 | M | Ethmoid sinus | ISP | – | – |
| 23 | 56 | M | Maxillary sinus | ISP | – | – |
| 24 | 81 | M | Nasal cavity | ISP with dysplasia | – | – |
| 25 | 70 | M | Frontal sinus | ISP with dysplasia | – | – |
| 26 | 64 | F | Nasal cavity | ISP with dysplasia | – | – |
| 27 | 63 | M | Frontal sinus | ISP with dysplasia | – | – |
| 28 | 53 | F | Sphenoid sinus | ISP with dysplasia | – | – |
| 29 | 79 | F | Nasal cavity | ISP with dysplasia | – | – |
| 30 | 55 | F | Maxillary sinus | SqCC ex ISP | – | – |
| Nasal cavity | SqCC ex ISP | – | – | |||
| 31 | 86 | F | Nasal cavity | SqCC ex ISP | – | – |
| 32 | 51 | M | Nasal cavity | SqCC ex ISP | – | – |
| 33 | 77 | M | Maxillary sinus | SqCC ex ISP | – | – |
| 34 | 49 | M | Nasal cavity | SqCC ex ISP | – | – |
| 35 | 46 | F | Ethmoid sinus | SqCC ex ISP | + | – |
| 36 | 51 | F | Frontal sinus | SqCC ex ISP | – | – |
| 37 | 58 | M | Nasal cavity | SqCC ex ISP | – | – |
| 38 | 62 | M | Maxillary sinus | SqCC ex ISP | – | – |
| 39 | 61 | F | Maxillary sinus | SqCC ex ISP | – | – |
| 40 | 75 | M | Maxillary sinus | SqCC ex ISP | – | – |
| 41 | 87 | F | Maxillary sinus | SqCC ex ISP | – | – |
| 42 | 74 | M | Maxillary sinus | SqCC ex ISP | – | – |
| 43 | 63 | F | Ethmoid sinus | SqCC ex ISP | – | – |
| 44 | 58 | F | Sphenoid sinus | SqCC ex ISP | – | – |
| 45 | 70 | M | Maxillary sinus | NKSqCC, inverted | – | – |
| 46 | 47 | F | Frontal sinus | NKSqCC, inverted | + | – |
| 47 | 63 | F | Nasal cavity | NKSqCC, inverted | + | + |
| 48 | 63 | M | Nasal cavity | NKSqCC, inverted | - | – |
| 49 | 71 | M | Nasal cavity | NKSqCC, inverted | – | – |
| 50 | 81 | M | Nasal cavity | NKSqCC, inverted | + | + |
| 51 | 37 | M | Sphenoid sinus | NKSqCC, inverted | – | – |
IHC Immunohistochemistry, ISH In situ hybridization for high-risk HPV types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73 and 82; M male, F female, ISP inverted Schneiderian papilloma, SqCC squamous cell carcinoma, NKSqCC non-keratinizing squamous cell carcinoma