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. 2017 Aug 8;11:146. doi: 10.3389/fnbeh.2017.00146

Figure 6.

Figure 6

Effect of subchronic and chronic exposure to GBH on serotoninergic neurons. (A) Photomicrographs of mice brain cross sections showing the serotonin (5-HT)-immunoreactive neurons across the rostral to the caudal extent of the dorsal raphe nucleus (DRN) after subchronic exposure. (B) The intensity of 5-HT immunoreactivity at the DRN in control and treated mice following chronic exposure. (C,D) The intensity of 5-HT immunoreactivity at the DRN in control and treated mice. Aq, Cerebral aqueduct. DRD, dorsal raphe dorsal (dorsomedial), DRV, dorsal raphe ventral (ventromedial). Results are presented as mean ± SEM. ***P < 0.001. The *** refers to the control vs. 250 mg/kg and 500 mg/kg group comparison and the “#” refers to the 250 mg/kg vs. 500 mg/kg group comparison. ##P < 0.01, ###P < 0.001: the post hoc analysis.