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. 2017 Aug 9;7:7642. doi: 10.1038/s41598-017-06588-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CFTR interactome in HBE41o- and CFBE41o- cells. (a) CFTR was isolated from WT HBE41o- and ΔF508 CFBE41o- cells and the resulting CFTR immunocomplexes were subjected to mass spectrometry analysis. An experimental schematic is shown. An experimental schematic is shown. The schematic was produced, in part, by using Servier Medical Art, (www.servier.com/Powerpoint-image-bank). (b) The number of proteins identified by mass spectrometry were displayed using Venny Software. Proteins identified in the CFTR interactomes were overlaid onto global molecular networks, developed from information contained in the Ingenuity knowledge database. Canonical pathways significantly associated with proteins (p < 0.05) in the WT CFTR interactome (c) and ΔF508 CFTR interactome (d) are displayed.