Table 1.

Correlations of signature coefficients.

Row	The human or human-mouse dataset from which the signature(s) were extracted, and the number of the signature, based on the order of the signatures extracted by NMF/the total number of NMF signatures extracted	P123+IRmse+Uremse 1/4 (UV signature)	P123+IRmse+Uremse 2/4 (IRa signature)	P123+IRmse+Uremse 4/4 (IRb signature)	P123+IRmse+Uremse 3/4 (urethane signature)
Correlations among the four signatures extracted from the P123+IRmse+Uremse dataset
1.	P123+IRmse+Uremse 1/4 (UV signature)	1
2.	P123+IRmse+Uremse 2/4 (IRa signature)	0.144	1
3.	P123+IRmse+Uremse 4/4 (IRb signature)	−0.020	0.369	1
4.	P123+IRmse+Uremse 3/4 (urethane signature)	−0.114	0.238	0.027	1
Correlations with the normalized WTSI signatures correlated most highly with the UV, IRa, IRb and urethane signatures
5.	WTSI sig n7	0.970	0.039	−0.082	−0.146
6.	WTSI sig n6	0.335	0.853	0.463	0.229
7.	WTSI sig n14	0.185	0.816	0.421	0.282
8.	WTSI sig n17	0.165	0.020	0.698	−0.120
9.	WTSI sig n8	0.169	0.539	0.323	0.421
10.	WTSI sig n5	0.266	0.576	0.261	0.416
Correlations with signatures extracted from alternative datasets
14.	P3 1/1	0.999	0.153	−0.014	−0.109
15.	P123 1/2	0.999	0.151	−0.015	−0.110
16.	P123 2/2	0.314	0.795	0.521	0.270
17.	P123+IRmse 1/3	1.000	0.151	−0.014	−0.109
18.	P123+IRmse 2/3	0.192	0.996	0.349	0.275
19.	P123+IRmse 3/3	−0.013	0.483	0.974	0.138
20.	P12+IRmse 1/2	0.649	0.842	0.250	0.149
21.	P12+IRmse 2/2	0.019	0.534	0.955	0.168

We pooled the normalized data for Patients 1, 2 and 3 (the P123 dataset) with the normalized data for the IR-induced mouse malignancies (the IRmse dataset), and with normalized data for 22 samples from urethane-induced mouse malignancies. Correlations with the normalized WTSI signatures correlated most highly with the UV, IRa, IRb and urethane signatures are shown in rows 5–10.