Table 2.

Correlations of the four signatures from the P123+IRmse+Uremse dataset with signatures from only the irradiated mouse samples, IRmse, with and without normalizing frequencies before NMF.

Row	The human or human-mouse dataset from which the signature(s) were extracted, and the number of the signature, based on the order of the signatures extracted by NMF/the total number of NMF signatures extracted	The signatures extracted from the pooled P123+IRmse+Uremse dataset after normalizing and shown in Fig. 3A:
		P123+IRmse+Uremse 1/4 (UV signature)	P123+IRmse+Uremse 2/4 (IRa signature)	P123+IRmse+Uremse 4/4 (IRb signature)	P123+IRmse+Uremse 3/4 (urethane signature)
1.	IRmse 1/2	0.642	0.848	0.255	0.152
2.	IRmse 2/2	−0.023	0.382	0.981	0.083
Correlations with the 96 trinucleotide-type, normalized counterpart of the Cell Reports (CellR) 3 signatures for mouse-only data
3.	IRmse 1/3	0.436	0.921	0.299	0.240
4.	IRmse 2/3	0.779	0.521	0.151	−0.017
5.	IRmse 3/3	−0.033	0.299	0.980	0.042
Correlations with the 96 trinucleotide-type, un-normalized counterpart of the 192 trinucleotide-type Cell Reports (CellR) 3 signatures for mouse data
6.	CellR 1/3	0.530	0.266	−0.004	−0.071
7.	CellR 2/3	0.305	0.688	0.060	0.172
8.	CellR 3/3	−0.095	−0.013	0.840	−0.046

Table 2 shows the correlations for (1) four signatures extracted from the pooled P123+IRmse+Uremse dataset shown in Fig. 3A, with normalized NMF input frequencies, (2) three signatures extracted from the IRmse dataset only, with normalized NMF input frequencies, and (3) three signatures extracted from the IRmse dataset, but with un-normalized frequencies. Of the three NMF-derived signatures for the normalized IRmse data, the first of the three signatures is correlated 0.92 with the IRa signature, and the third of these signatures is correlated 0.98 with the IRb signature.