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. 2017 Aug 9;7:7652. doi: 10.1038/s41598-017-07967-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Location of rs7426056 single nucleotide polymorphism on CD28 locus. Rs7426056 SNP is located between CD28 and CTLA4 genes; approximately 3.5 kb downstream the CD28 3′UTR and approximately 120 kb upstream CTLA4 gene. Several risk variants in the CD28/CTLA4 locus have been associated with other autoimmune and immune-mediated diseases. Exons are indicated in black. (B) Table shows the linkage disequilibrium of rs7426056 with the other SNPs in CD28 and CTLA4 genes. PSC: primary sclerosing cholangitis, RA: rheumatoid arthritis, MS: multiple sclerosis, AA: alopecia areata, CEL: celiac disease.