Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 9;7:7652. doi: 10.1038/s41598-017-07967-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

AA, AG and GG individuals express similar levels of ICOS, OX40 and PD-1 molecules after T cell activation. CD4⁺CD25⁻ T cells were activated in vitro with aCD3 antibody and CHO-CD80 cell line in the presence or absence of 1,25(OH)₂D₃ for 5 days. (A) Representative flow cytometry plots showing proliferating T cells expressing ICOS, OX40 and PD-1. (B) Percentage of proliferating cells that express ICOS, OX40 and PD-1 under no vitamin D treatment conditions (VitD−). (C–E) Data show the percentage of proliferating cells that express ICOS, OX40 and PD-1 and their respective median fluorescence intensity values for GG, AA and AG genotypes of the PSC CD28 risk allele locus. Representative overlay histograms showing the expression of each marker in the presence and absence of 1,25(OH)₂D₃. *p < 0.05, ***p < 0.001, ****p < 0.0001 using Wilcoxon matched-pairs signed rank test.