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. 2017 Aug 9;7:7703. doi: 10.1038/s41598-017-08140-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IGF-1R stimulates polarity switch of migrating neurons. (a) shRNA-IGF-1R (center) decreases the proportion of bipolar cells in the radial migration zone (RMZ) at E17 compared to a control vector (left). Co-electroporation of shRNA-IGF-1R and IGF-1 OPT rescued normal polarization (right). (b) Cell morphologies of shRNA-IGF-1R and control cells are shown at higher magnification at the RMZ and multipolar marginal zone MMZ Calibration bar = 50 μm. (c) Quantification of in the morphologies of cells located in the RMZ from a. Student’s t test; ***p-value = 0.002. n = 3 independent experiments. An average of 100 cells was scored for each condition.