. 2017 Aug 9;7:7668. doi: 10.1038/s41598-017-08185-6

Table 2.

Characteristics of the POP datasets in the Gene Expression Omnibus (GEO) database repository.

Dataset	Reference	Tissue	Number of samples	GEO accession no; Platform	Number of DEG^a with FDR-corrected P - value < 0.05	Number of DEG^a with FC ≥ 2.0 and P - value < 0.05 (uncorrected for multiplicity)
PrM Caucasian women (cystocele POP-Q stage ≥ 2), n = 12	Citation missing	AVW (POP site) versus precervical AVW (non POP site)	12 women (24 samples)	GSE53868; GPL18142 Agilent-014850 WHGM 4 × 44K G4112F	50 (↑ 31; ↓ 19)	74 (↑ 58; ↓16)
PrM POP women, n = 5^b	Brizzolara et al.¹³	RLs	5	GSE12852; GPL2986 ABI Human Genome Survey Microarray Version 2	PrM_RLs set 0	PrM_RLs set 287 (↑ 246; ↓ 41)
PrM POP women, n = 5^b		USLs	5		PrM_RLs set 0	PrM_RLs set 287 (↑ 246; ↓ 41)
PrM controls, n = 6^b		RLs	6		PrM_USLs set 0	PrM_USLs set 972 (↑ 949; ↓23)
PrM controls, n = 6^b		USL	6		PrM_USLs set 0	PrM_USLs set 972 (↑ 949; ↓23)
PM POP women, n = 3^b		RL	3		PM_RLs set 0	PM_RLs set 485 (↑ 345; ↓ 140)
PM POP women, n = 3^b		USL	3		PM_RLs set 0	PM_RLs set 485 (↑ 345; ↓ 140)
PM controls, n = 3^b		RL	3		PM_USLs set 2 (↑ 2; ↓ 0)	PM_USLs set 494(↑ 263; ↓ 231)
PM controls, n = 3^b		USL	3		PM_USLs set 2 (↑ 2; ↓ 0)	PM_USLs set 494(↑ 263; ↓ 231)

^a↑ up-regulation; ↓ down-regulation; ^bMixed ethnicity.

Abbreviations: AVW, anterior vaginal wall; DEG, differently expressed genes; FC, fold change; FDR, false discovery rate; WHGM, whole human genome microarray; PM, postmenopausal; PrM, premenopausal; RLs, round ligaments; USLs, uterosacral ligaments.