Table 1.
Bioinformatic analysis of putative-binding motifs for NF-κB and p53
| Transcription factor | Gene | Number of binding motifs identified within 2 kbps at 70% confidence | Minimum distance from transcription start site (TSS) at 70% confidence |
|---|---|---|---|
| p65 | SCO2 | 12 | 94 |
| TFAM | 9 | 38 | |
| POLRMT | 14 | 157 | |
| CYB5A | 15 | 696 | |
| IL1A | 16 | 47 | |
| TP53 (p53) | 9 | 958 | |
| NF-κB p65 (RelA) | 9 | 426 | |
| p53 | SCO2 | 1 | 822 |
| TFAM | 1 | 1863 | |
| POLRMT | 1 | 1985 | |
| CYB5A | 4 | 322 | |
| CDKN1A | 3 | 188 | |
| NF-κB p65 (RelA) | 3 | 349 | |
| TP53 (p53) | 1 | 423 |
Putative-binding motifs for NF-κB p65 (RelA) and p53 transcription factors on the DNA of SCO2, POLRMT, TFAM, CYB5A, TP53, and RELA genes shown in the table displays number of possible binding sites and distance from transcription start site at a confidence level of 70%; Red fonts IL1A and CDKN1A are known to be positively regulated genes by p65 and p53, respectively