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. 2017 Aug 9;7:7630. doi: 10.1038/s41598-017-06737-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes between super-shedders and non-shedders. (A) Number of differentially expressed (DE) genes identified in intestinal regions. DE genes: FDR < 0.05, log2(fold change) <−1 or >1, cpm ≥1 in at least 50% of SS and NS. (B) and (C) are Heatmaps for log₂(counts per million) of differentially expressed genes in all tissues: (B) up-regulated differentially expressed genes in super-shedders; (C) down-regulated differentially expressed genes in super-shedders. Scaled log2(counts per million) was indicated by red and blue colors, and red indicates higher expression level, while blue colour indicates lower expression level. The column labels indicate super-shedders and non-shedders: NS, non-shedders; SS, super-shedders. The row labels indicate the tissue where differentially expressed genes were identified. DU, duodenum; PJ, proximal jejunum; DJ, distal jejunum; CE, cecum; SC, spiral colon; DC, descending colon.