Table 1.
Gene ontology (GO) term enrichment (biological process, p-value < 0.05) for DE genes between non-shedders and super-shedders in distal jejunum and descending colon, no functional terms were enriched for other tissues (p-value ≥ 0.05).
| GO Terms | Fold enrichment*** | Genes |
|---|---|---|
| Up-regulated genes in DJ* | ||
| regulation of interferon-gamma production | 22.6 | LOC100848575, IL1RL1, PD-L1, KLRK1, IL18R1 |
| positive regulation of inflammatory response | 22.6 | IL1RL1, CD6, IDO1, CCL2, GBP5 |
| immune response-activating cell surface receptor signaling pathway | 22.5 | LOC100848575, PTPN22, IKT, THEMIS, ICP2, KLRK1 |
| negative regulation of homotypic cell-cell adhesion | 22.0 | PTPN22, ADAMTS18, ALOX12, PD-L1, IDO1 |
| positive regulation of cytokine production | 12.2 | LOC100848575, PTPN22, IL1RL1, IL1A, PD-L1, CD6, KLRK1, IL18R1, IDO1, GBP5 |
| negative regulation of immune system process | 9.5 | PTPN22, IL1RL1, GPR171, PD-L1, KLRK1, IDO1, CCL2, GPR55 |
| cytokine-mediated signaling pathway | 8.8 | CXCL10, IL1RL1, IL1A, CXCL9, CCR9, IL18R1, F3, CCL2 |
| leukocyte activation | 8.4 | LOC100848575, PTPN22, BATF2, LCP2, ITK, CD6, KLRK1, IL18R1, THEMIS |
| immune response | 8.1 | BOLA-NC1, CLNK, CXCL10, TNFSF10, IL1A, LCP2, ITK, PD-L1, CD6, CXCL9, CCR9, CD1D, IL18R1, THEMIS, CCL2, LOC407111, GBP5, F1N3I2 |
| positive regulation of intracellular signal transduction | 5.4 | CXCL10, TNFSF10, PTPN22, IL1A, CXCL9, IL8R1, F3, NRG1, CCL2, PPR55, LOC407111 |
| defense response | 5.0 | CXCL10, BATF2, IL1A, ITK, CD6, CXCL9, KLRK1, F3, IDO1, CCL2, GBP5, IFI47 |
| Down-regulated genes in DJ | ||
| regulation of nuclease activity | 33.8 | HMGB1, NEIL1, PCNA, LOC618297 |
| base-excision repair | 21.1 | HMGB1, NEIL1, NEIL3, MUTYH, UNG, LIG1 |
| nucleosome assembly | 7.5 | H2B1, HIST1H2BJ, HMGB1, HIST1H2BI, HIST1H1C, DCK, HIST1H1A, HIST1H1E, HIST1H1D |
| Up-regulated genes in DC** | ||
| Cholesterol import | >100 | APOA1, CD36 |
| Cholesterol transport | 95.5 | APOB, APOA1, CD36 |
| Sterol transport | 90.9 | APOB, APOA1, CD36 |
| Sterol import | >100 | APOA1, CD36 |
| Triglyceride metabolic process | 93.2 | APOB, APOA1, AGPAT9 |
*Distal jejunum.
**Descending colon.
***Number of genes observed in the uploaded list over the expected number genes involved in that term for Bos taurus (which is determined by the Gene Ontology database).