. 2017 Aug 9;7:7671. doi: 10.1038/s41598-017-08110-x

Table 1.

Impact of PrP^C depletion on cell sensitivity to sTNFα in 1C11 precursor cells, 1C11^5-HT neuronal cells and primary CGNs.

	LD₅₀ ^TNFα (ng ml⁻¹)
	WT	PrP^null/PrP^0/0
1C11	70 ± 10	8.1 ± 1.5
1C11^5-HT	8.1 ± 1.2	1.5 ± 0.3
CGN	100 ± 20	5.2 ± 3.1

LD₅₀ ^TNFα values correspond to the concentration of sTNFα inducing a 50% cell death in 1C11 and 1C11^5-HT cells or inducing dendritic fragmentation for 50% of neuronal cells in CGNs. Data are the mean ± SEM of three independent experiments performed in triplicate.