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. 2017 Aug 9;7:7654. doi: 10.1038/s41598-017-06837-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-modal computational imaging of apoptotic HeLa cells induced by paclitaxel. The phase is reconstructed every second from the beginning of the drug treatment. (a) 5 representative quantitative phase images spanning over 1 h. (b) Magnified views at different time points corresponding to regions of interest (Areas 1 and 2). (c) Dry mass changes of three labeled cells during apoptosis. (d) Simulated phase contrast and DIC images at three time points.