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Adjusted hazard ratios for overall survival by subgroup for patients receiving second-line chemotherapy versus second-line androgen receptor-targeted therapy. aHR adjusted hazard ratio, ALP alkaline phosphatase, CI confidence interval, LDH lactate dehydrogenase, LLN lower limit of normal, PSA prostate-specific antigen, ULN upper limit of normal. a Based on Halabi et al. [18]. * Denotes significant p value at the 5% level
