Fig. 4.

Effect of the hERG allosteric modulator LUF7346 on field potential (FP) and action potential (AP) duration in LQT2 hiPSC-CMs. a Representative FP traces showing the effect of increasing concentrations of LUF7346 on FP duration measured in LQT2 hiPSC-CMs carrying the N996I mutation (LQT2^N996I). b Representative AP traces from LQT2^N996I hiPSC-CMs under baseline conditions (Tyrode) and after application of increasing concentrations of LUF7346 (color-code panels are shown in the insets). LUF7346 reduced FP and AP duration in LQT2^N996I hiPSC-CMs. Figure modified from [14]