Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 8;8:105. doi: 10.3389/fgene.2017.00105

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Liu, Wang, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Sequence alignment and structure analysis results. IGF2 is evolutionarily conserved across species (A). The mutated site (dashed circle) is in adjacent to the first α helix of IGF2 in both free and binding states (B). Schematic drawing of the binding sites (red boxes) of IGF2 with its two different binding partners (Ca: yellow, IGF2R; green, IGF2 antibody). Detailed interaction of G10 with its binding sites (Cb). Binding surface of the local region on IGF2 around G10 is negatively charged (Cc).