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. 2017 Aug 8;11:232. doi: 10.3389/fncel.2017.00232

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Copyright © 2017 Shi, Ko and Ko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deletion of RS1 decreases the protein expression of Cav1.3 and Cav1.4. (A) The upper panel (a1-c5) contains retinal sections of wild type (WT), and the lower panel (d1-f5) contains retinal sections of RS1^−/−. (a1-a2) and (d1-d2) are the immunostaining for RS1. (b1-b5) and (e1-e5) are the double immunostaining for Cav1.3 and Ribeye; (c1-c5) and (f1-f5) are the double immunostaining for Cav1.4 and Ribeye. The scale bar represents 50 μm. (B) The same immunostained retinal sections are shown at a higher magnification (40×). The upper panel contains retinal sections from WT (a1-a5) and RS1^−/− (b1-b5) that were double-stained for Cav1.3 and Ribeye. Images in (a1-a5) and (b1-b5) include retinal layers of IS, ONL, OPL and INL. The lower panel contains retinal sections from WT (c1-c5) and RS1^−/− (d1-d5) that were double-stained for Cav1.4 and Ribeye. Images in (c1-c5) and (d1-d5) include retinal layers of ONL, OPL and INL. The scale bar represents 50 μm. 4′s,6-diamidino-2-phenylindole (DAPI) stains the nuclei. BF, bright field; IS, photoreceptor inner segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer.