FIG 3 .

Double-strand break repair within subtelomeric regions in response to X-ray irradiation. (A) Two products of telomere healing are shown. On chromosome 1 (top), telomere repeats were inserted into the coding region of the rif gene (Pf3D7_0101900) and on chromosome 2 (bottom), in which telomere repeats were inserted into the hypothetical gene Pf3D7_0221000. These events resulted in subtelomeric deletion of ~90 and ~100 kb, respectively. (B) Three products of repair by homologous recombination were also identified, two on chromosome 12 (top) and one on chromosome 13 (bottom). The two events on chromosome 12 resulted in the insertion of subtelomeric sequences from chromosomes 1 and 9; however, no coding regions were altered. The event on chromosome 13 resulted in the insertion of 25,493 bp of sequence from chromosome 9 and led to the creation of a new var gene that is a chimera of Pf3D7_1300100 (blue) and Pf3D7_0900100 (pink).