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Schematic representation of ATP homeostasis and cellular regulation of cellobiose fermentation. Excess ATP inhibited phosphofructokinase (Pfk1), resulting in an upper glycolytic metabolite buildup and slow cellobiose consumption. The buildup of ATP may be caused by low activity of Pma1, with no phosphorylation at position 911. Additionally, glucose sensors Snf3 and Rgt2 together influenced cellular ATP levels via Pma1 and other mechanisms yet to be identified.
