Table 1.
Clinical characteristics of patients with severe hypoxic hepatitis n (%)
| n = 75 | |
| Demographics | |
| Age | 61.9 ± 16.6 |
| Male gender | 43 (57.3) |
| Race (Chinese/Malay/Indian) | 51/20/4 (68/26.7/5.3) |
| Pre-existing co-morbidities | |
| Pre-existing ischemic heart disease | 41 (54.7) |
| Pre-existing cardiac failure | 27 (36.0) |
| Pre-existing renal failure | 27 (36.0) |
| Pre-existing chronic viral hepatitis | 5 (6.7) |
| Precipitating conditions | |
| Documented hypotension | 55 (73.3) |
| Documented bradycardia | 11 (14.7) |
| Documented metabolic acidosis | 43 (57.3) |
| Baseline laboratory parameters1 | |
| Albumin (g/L) | 25.3 ± 6.9 |
| Bilirubin (μmol/L) | 76.1 ± 82.6 |
| GGT (U/L) | 126 ± 90 |
| Creatinine (mmol/L) | 321 ± 211 |
| Prothrombin time (seconds) | 27.8 ± 12.2 |
| ALT (U/L) | 2295 ± 1656 |
| AST (U/L) | 4896 ± 2986 |
| ALT/AST ratio_D12 | 0.70 ± 1.36 |
| Peak ALT (U/L) | 2834 ± 1938 |
| Peak AST (U/L) | 5894 ± 3148 |
| Clinical outcome | |
| Admitted to ICU | 50 (66.7) |
| Died within same admission | 53 (70.7) |
1
Measured at onset of severe hypoxic hepatitis;
2
Ratio of the ALT to AST at the first documentation of either ALT or AST > 3000U/L. AST: Aspartate transaminase; ALT: Alanine transaminase; GGT: Gamma glutamyl transferase; ICU: Intensive care unit.