Table 3. Simulation results for time-to-event outcomes generated from a proportional hazards regression model.

10,000 replications of 400 patients; casemix-corrected c-index based on 25 resampled outcomes per patient.

Simulation settings						Benchmark performance			Overall performance
	Case-mix		Coefficients			case-mix corrected c-index	mbc = mbc(Xβ)	SE[mbc]	Calibration slope $\widehat{\gamma }$	c-index	c-mbc = mbc( $\widehat{\gamma }$Xβ)	SE[c-mbc]
	Sd(x1)	p(x2)	β0	β1	β2
A	1	0.2	−2	1	1	0.736 (0.0062)	0.736 (0.0057)	0.0056	1.003 (0.064)	0.736 (0.013)	0.737 (0.011)	0.011
B	0.8	0.2	−2	1	1	0.708 (0.0059)	0.708 (0.0055)	0.0054	1.004 (0.072)	0.708 (0.014)	0.709 (0.012)	0.012
C	1.2	0.2	−2	1	1	0.760 (0.0061)	0.761 (0.0056)	0.0057	1.003 (0.059)	0.761 (0.012)	0.761 (0.011)	0.011
D	1	0.1	−2	1	1	0.731 (0.0062)	0.731 (0.0057)	0.0056	1.004 (0.065)	0.732 (0.013)	0.732 (0.011)	0.011
E	1	0.4	−2	1	1	0.742 (0.0061)	0.742 (0.0056)	0.0056	1.003 (0.063)	0.742 (0.013)	0.742 (0.011)	0.011
F	1	0.2	−2	0.8	1	0.736 (0.0062)	0.736 (0.0057)	0.0056	0.826 (0.059)	0.707 (0.014)	0.707 (0.012)	0.012
G	1	0.2	−2	1.2	1	0.736 (0.0062)	0.736 (0.0056)	0.0056	1.168 (0.068)	0.760 (0.012)	0.760 (0.011)	0.011
H	1	0.2	−2	1	0.5	0.736 (0.0059)	0.736 (0.0056)	0.0056	0.901 (0.063)	0.723 (0.013)	0.720 (0.012)	0.011
I	1	0.2	−2	1	2	0.736 (0.0061)	0.736 (0.0056)	0.0056	1.057 (0.067)	0.748 (0.013)	0.745 (0.011)	0.011