TABLE 3.
UNIVARIATE ANALYSIS OF ABCC8 SNP ASSOCIATION WITH CEREBRAL EDEMA IN TBI
| SNP | Acute CT Edema | Average ICP | Peak ICP | Decompressive Craniotomy | |||||
|---|---|---|---|---|---|---|---|---|---|
| Odds Ratio (95% CI) | p | β-coefficient (95% CI) | p | β-coefficient (95% CI) | p | Odds ratio (95% CI) | P | ||
| rs2283261 Intron 10 |
Homozygous major (AA) | 1.23 (0.78–1.94) | 0.38 | −0.51 (−2.04–1.01) | 0.51 | 1.56 (−2.4–5.5) | 0.44 | 0.97 (0.62–1.51) | 0.91 |
| Homozygous minor (CC) | 2.46 (1.29–4.69) | 0.006 | 3.70 (1.85–5.56) | 0.000 | 8.29 (3.42–13.17) | 0.001 | 1.005 (0.55–1.85) | 0.99 | |
| Heterozygous (AC) | 0.54 (0.35–0.84) | 0.006 | −1.57 (−2.98–−0.16) | 0.029 | −5.87 (−9.48–−2.27) | 0.002 | 1.023 (0.67–1.56) | 0.91 | |
| Allele A | 0.41 (0.21–0.77) | 0.006 | −3.70 (−5.56–−1.84) | 0.000 | −8.29 (−13.2–−3.42) | 0.001 | 1.00 (0.54–1.83) | 0.99 | |
| Allele C | 0.82 (0.52–1.29) | 0.38 | 0.52 (−1.01–2.04) | 0.51 | −1.56 (−5.52–2.41) | 0.44 | 1.03 (0.66–1.60) | 0.90 | |
|
| |||||||||
| rs3819521 Intron 3 |
Homozygous major (CC) | 1.37 (0.88–2.13) | 0.16 | −0.17 (−1.62–1.28) | 0.82 | 2.24 (−1.51–6.00) | 0.24 | 1.18 (0.77–1.81) | 0.45 |
| Homozygous minor (TT) | 2.43 (1.16–5.13) | 0.019 | 3.42 (1.29–5.55) | 0.002 | 8.23 (2.67–13.80) | 0.004 | 0.85 (0.42–1.72) | 0.65 | |
| Heterozygous (CT) | 0.53 (0.34–0.82) | 0.005 | −1.29 (−2.7–0.12) | 0.07 | −5.67 (−9.29–−2.06) | 0.002 | 0.90 (0.59–1.38) | 0.64 | |
| Allele C | 0.41 (0.19–0.87) | 0.019 | −3.42 (−5.55–−1.29) | 0.002 | −8.23 (−13.8–−2.67) | 0.004 | 1.18 (0.58–2.41) | 0.65 | |
| Allele T | 0.73 (0.47–1.13) | 0.16 | 0.17 (−1.28–1.62) | 0.82 | −2.24 (−6.00–1.51) | 0.24 | 0.85 (0.55–1.30) | 0.45 | |
|
| |||||||||
| rs2283258 Intron 7 |
Homozygous major (GG) | 1.23 (0.80–1.91) | 0.72 | −0.41 (−1.84–1.01) | 0.57 | 1.36 (−2.35–5.07) | 0.47 | 0.99 (0.65–1.52) | 0.97 |
| Homozygous minor (AA) | 3.13 (1.32–7.42) | 0.01 | 3.84 (1.49–6.28) | 0.002 | 7.80 (1.40–14.21) | 0.017 | 1.00 (0.46–2.21) | 0.99 | |
| Heterozygous (GA) | 0.58 (0.38–0.91) | 0.016 | −0.84 (−2.27–0.58) | 0.25 | −3.92 (−7.60–−0.25) | 0.037 | 1.01 (0.66–1.54) | 0.97 | |
| Allele G | 0.32 (0.18–0.76) | 0.010 | −3.84 (−6.28–−1.40) | 0.002 | −7.80 (−14.21–−1.4) | 0.017 | 1.00 (0.45–2.20) | 0.99 | |
| Allele A | 0.81 (0.52–1.25) | 0.34 | -.41 (−1.01–1.84) | 0.57 | −1.36 (−5.07–2.35) | 0.47 | 1.01 (0.66–1.54) | 0.97 | |
|
| |||||||||
| rs1799857 Exon 12 |
Homozygous major (GG) | 0.67 (0.42–1.07) | 0.096 | 0.85 (−0.64–2.32) | 0.26 | 2.02 (−1.83–5.87) | 0.3 | 0.47 (0.29–0.77) | 0.002 |
| Homozygous minor (AA) | 1.20 (0.69–2.08) | 0.52 | −0.83 (−2.71–1.05) | 0.39 | −0.60 (−5.50–4.30) | 0.81 | 1.36 (0.80–2.30) | 0.26 | |
| Heterozygous (GA) | 1.26 (0.82–1.95) | 0.29 | −0.303 (−1.73–1.12) | 0.68 | −1.52 (−5.22–2.19) | 0.42 | 1.54 (1.004–2.36) | 0.048 | |
| Allele G | 0.83 (0.48–1.45) | 0.52 | 0.83 (−1.05–2.71) | 0.39 | 0.60 (−4.30–5.50) | 0.81 | 0.74 (0.43–1.25) | 0.26 | |
| Allele A | 1.49 (0.93–2.39) | 0.096 | −0.85 (−2.32–0.64) | 0.26 | −2.02 (−5.88–1.84) | 0.30 | 2.13 (1.31–3.47) | 0.002 | |
Table 3: Univariate analyses demonstrating the association of each of the 4 SNPs with measures of cerebral edema including mean and peak ICP, acute CT edema, and need for decompressive craniotomy. Odds ratios (OR) are provided for binary outcomes (CT edema, decompressive craniotomy), and βcoefficients for continuous outcomes (mean and peak ICP).