TABLE 4.

MULTIVARIATE ANALYSIS OF ABCC8 SNP ASSOCIATION WITH MEASURES OF CEREBRAL EDEMA IN TBI

SNP		Acute CT Edema		Average ICP		Peak ICP		Decompressive Craniotomy
		Odds Ratio (95% CI)	p	β-coefficient (95% CI)	p	β-coefficient (95% CI)	p	Odds ratio (95% CI)	P
rs2283261	Homozygous minor (CC)	2.45 (1.28–4.70)	0.007	3.13 (1.50–5.13)	0.000	8.00 (3.13–12.86)	0.001	0.99 (0.53–1.87)	0.99
	Heterozygous (AC)	0.53 (0.34–0.83)	0.005	−1.20 (−2.56–−0.16)	0.084	−5.17 (−8.74–−1.60)	0.005	0.96 (0.61–1.48)	0.84
	Allele A	0.41 (0.21–0.78)	0.007	−3.31 (−5.13–−1.50)	0.000	−8.00 (−12.86–−3.13)	0.001	1.01 (0.53–1.89)	0.99
rs3819521	Homozygous minor (TT)	2.36 (1.11–5.01)	0.025	2.95 (0.88–5.02)	0.005	7.64 (2.11–13.16)	0.007	0.83 (0.40–1.74)	0.63
	Heterozygous (CT)	0.52 (0.33–0.82)	0.004	−0.70 (−2.08–0.69)	0.32	−4.61 (−8.24–−0.96)	0.013	0.80 (0.51–1.25)	0.33
	Allele C	0.42 (0.20–0.90)	0.025	−2.95 (−5.02–−0.88)	0.005	−7.64 (−13.2–−2.11)	0.007	1.20 (0.58–2.50)	0.63
rs2283258	Homozygous minor (AA)	3.00 (1.26–7.18)	0.013	3.20 (0.83–5.58)	0.008	6.89 (0.52–13.25)	0.034	1.03 (0.46–2.34)	0.94
	Allele G	0.33 (0.14–0.80)	0.013	−3.20 (−5.58–−0.83)	0.008	−6.89 (−13.25–−0.52)	0.034	0.97 (0.43–2.19)	0.94
rs1799857	Homozygous major (GG)	0.67 (0.42–1.08)	0.102	0.82 (−0.61–2.23)	0.26	1.90 (−1.88–5.68)	0.32	0.47 (0.28–0.78)	0.004
	Allele A	1.49 (0.92–2.39)	0.102	−0.81 (−2.23–0.61)	0.26	−90 (−5.68–1.88)	0.32	2.12 (1.28–3.51)	0.004

Table 4: Multivariate analyses demonstrating the association of each of the 4 SNPs with measures of cerebral edema including mean and peak ICP, acute CT edema, and need for decompressive craniotomy after controlling for age, gender, and initial GCS score. Adjusted Odds ratios (OR) are provided for binary outcomes (CT edema, decompressive craniotomy), and β-coefficients for continuous outcomes (mean and peak ICP).