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Improved renal function in mice with experimental diabetic nephropathy after IL-22 gene therapy. (a) Serum creatinine levels, (b) serum BUN levels, (c) proteinuria and (d) renal index of mice before and after IL-22 gene therapy for 12 weeks. Renal index=renal weight (mg)/body weight (g). N=5; *P<0.05; **P<0.01. The time point of the initiation of IL-22 gene therapy was defined as week 0
