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. 2017 Jul 27;8(7):e2963. doi: 10.1038/cddis.2017.360

Table 1. Potential membrane proteins interact with ASM on T cells.

Membrane proteins Downstream signals Effects of ASM on the signals References
CD3 ZAP70-PLC-γ1-MAPK/JNK T-cell activation, proliferation, differentiation; IL-2 production 4
CD28 PI3K-Akt-mTOR T-cell activation, proliferation, differentiation; IL-2 production 4, 32
TNFR1? Ca2+ signal Inhibition of Ca2+ influx and responses 31
CD95? Apoptosis-related signal Mediating CD95-induced apoptosis 43
CD39, CD161 mTOR, STAT3 Induction of human Th17 3