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. 2017 Aug 9;5:95. doi: 10.1186/s40168-017-0312-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Statins alter the overall composition of the bile acid pool in the gut. a Relative levels of the indicated primary and secondary bile acids in the faecal content of the caecum of mice control (white) or mice treated with pravastatin (grey) or atorvastatin (black) and fed with ND. Bars represent the mean ± SD calculated from at least four biological replicates. b Relative expression in the liver of Cyp7a1 and Cyp27a1 by qPCR. Data are represented as the mean ± SD determined from at least three biological replicates. n.s. non-significant; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; one-way ANOVA and pairwise comparisons by Dunnett’s post hoc test