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. 2017 Aug 9;5:95. doi: 10.1186/s40168-017-0312-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — PXR activity regulates the changes in the BA pool of the gut induced by statins. a Relative levels of the indicated primary and secondary bile acids in the gut of Pxr ^−/− mice control (white) or mice treated with pravastatin (grey) or atorvastatin (black) and fed with ND. Bars represent the mean ± SD calculated from at least four biological replicates. b Relative expression in the liver of Cyp7a1 and Cyp27a1 by qPCR. Barplots represent the mean ± SD determined from three biological replicates. **P ≤ 0.01; one-way ANOVA followed by Dunnett’s post hoc test