Table 1.
Baseline characteristics of the Mannheim Sepsis Study (MaSep) at day 1
| Controls (n = 77) |
Sepsis (n = 73) |
Septic Shock (n = 140) |
p-values | |
|---|---|---|---|---|
| Age, years (mean, range) | 64 (42–87) | 65 (26–88) | 67 (39–87) | 0.9 |
| Gender, n (%) | ||||
| Male | 42 (55) | 47 (64) | 101 (72) | <0.001 |
| Female | 35 (45) | 26 (36) | 39 (28) | 0.1 |
| Site of infection, n (%) | ||||
| Lung | - | 47 (64) | 84 (60) | 0.001 |
| Urinary tract | - | 9 (12) | 12 (8) | 0.5 |
| Abdominal | - | 10 (14) | 15 (11) | 0.3 |
| Central nervous system | - | 0 (0) | 0 (0) | - |
| Skin | - | 2 (3) | 8 (6) | 0.06 |
| Heart | - | 4 (6) | 4 (3) | 1.0 |
| Blood | - | 1 (1) | 10 (7) | 0.007 |
| Others | - | 0 (0) | 7 (5) | - |
| Laboratory values, mean ± SEM | ||||
| White blood cells (109/L) | - | 16.1 ± 1.4 | 18.1 ± 1.2 | 0.4 |
| Platelets, (10E9/L) | - | 221 ± 16.2 | 169 ± 9.9 | 0.01 |
| Bilirubin, mg/dl | - | 1.6 ± 0.4 | 3 ± 0.6 | 0.004 |
| Lactate mg/dl | - | 2.3 ± 0.2 | 3.5 ± 0.3 | 0.002 |
| Creatinine, mg/dl | - | 2.4 ± 0.2 | 2.8 ± 0.2 | 0.05 |
| C reactive proteine, mg/l | - | 186 ± 12.5 | 207 ± 9.5 | 0.2 |
| Procalcitonin, ng/ml | - | 12.5 ± 2.7 | 31 ± 5.7 | 0.002 |
| Interleukin 6, pg/ml | - | 16,281 ± 15,560 | 6802 ± 1911 | <0.001 |
| pCO2 (mmHg) | - | 37.9 ± 1.6 | 43.7 ± 1.6 | 0.02 |
| Positive blood cultures, n (%) | - | 28 (38) | 62 (44) | <0.001 |
| ICU parameters, mean ± SEM | ||||
| ICU days | - | 10 ± 1.1 | 14.6 ± 1.3 | 0.1 |
| Ventilation days | - | 4.3 ± 0.9 | 9.4 ± 1.1 | <0.001 |
| Catecholamine days | - | 2 ± 0.5 | 7.4 ± 0.6 | <0.001 |
| Renal replacement therapy days | - | 1 ± 0.3 | 4.2 ± 0.7 | <0.001 |
| APACHE II, mean ± SEM | - | 20.5 ± 0.9 | 27.6 ± 0.6 | <0.001 |
| SOFA score, mean ± SEM | - | 7.2 ± 0.4 | 12.3 ± 0.3 | <0.001 |