Fig. 7.

PPP inhibits tumor growth in vivo and metastasis. Panel a: Tumor formation by RH30 cells inoculated into the hind limb muscles of SCID/Beige inbred mice. Six weeks later, mice were sacrificed and femora were harvested to evaluate the size of the growing tumor. Five mice formed control group and five were treated with PPP (40 mg/kg/24 h) After two weeks from inoculation we started intrapertitoneal injection of PPP and vehicle alone (50 μl DMSO). Panel b, c and d: the human RMS cells were detected by RQ-PCR in the bone marrows, lungs and livers harvested from mice inoculated with RH30 (controls and PPP-treated). *p < 0.05