Table 2.
The top twenty hub (based on node degree, D) and bottleneck (based on node betweenness, B) genes in the Exercise Response network in the Untrained Rest (UR) and Untrained Exercise (UE) states
| Untrained Rest | Untrained Exercise | Unique to Untrained Exercise | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hubs | D | Bottlenecks | B | Hubs | D | Bottlenecks | B | Hubs | D | Bottlenecks | B |
| GABARAPL1 | 33 | GABARAPL1 | 20,436 | GABARAPL1 | 25 | GABARAPL1 | 6905 | FN1 | 15 | FN1 | 888 |
| TCTN3 | 21 | ESR1 | 18,589 | FN1 | 19 | FN1 | 6881 | LIMA1 | 11 | LIMA1 | 826 |
| NDUFA6 | 19 | TRIM54 | 13,553 | LIMA1 | 16 | DNAJB1 | 6327 | APOA1 | 5 | FLNB | 756 |
| SIRT4 | 18 | GNB4 | 13,514 | NDUFA6 | 16 | CDC37 | 5983 | TRIM54 | 5 | APOA1 | 394 |
| FN1 | 16 | CDK18 | 13,394 | CDC37 | 14 | LIMA1 | 2799 | TMEM216 | 5 | CAV1 | 346 |
| GRB2 | 16 | CDC37 | 10,875 | MYO18A | 13 | TRIM54 | 2444 | ESR1 | 5 | ESR1 | 246 |
| NDUFA2 | 15 | FLNB | 10,484 | TMEM216 | 11 | HSPH1 | 2338 | BAG3 | 4 | TMEM216 | 210 |
| FASTKD3 | 15 | AHNAK | 10,125 | MYO19 | 10 | NR4A1 | 2210 | TCTN3 | 4 | TNS3 | 207 |
| ESR1 | 10 | MYO18A | 9786 | SPTBN1 | 9 | FLNB | 2123 | TUBB3 | 4 | RAB1A | 158 |
| TRIM54 | 9 | TCTN3 | 9292 | TRIM54 | 8 | SMAD3 | 2094 | FLNB | 4 | TUBB3 | 156 |
| NCK1 | 9 | GRB2 | 8676 | ESR1 | 8 | APOA1 | 1759 | PIK3R1 | 4 | AHNAK | 120 |
| MEOX2 | 8 | FN1 | 7852 | TCTN3 | 7 | CAV1 | 1707 | SMAD3 | 3 | KIT | 107 |
| ATP5F1 | 8 | HOMER3 | 7598 | FLNB | 7 | RARG | 1691 | KIT | 3 | SCRIB | 106 |
| CDC37 | 8 | ZBTB4 | 7364 | MEOX2 | 6 | TMEM216 | 1659 | TNS3 | 3 | FAS | 54 |
| TMEM216 | 8 | CCDC57 | 7154 | ATP5F1 | 6 | ESR1 | 1603 | CAV1 | 3 | DMWD | 54 |
| ACAD9 | 7 | CEP57L1 | 6650 | SYNPO | 6 | SPTBN1 | 1484 | CETN3 | 3 | ITPR3 | 54 |
| PCM1 | 7 | PCM1 | 6593 | SMAD3 | 5 | RAB1A | 1322 | RAB1A | 3 | FASN | 54 |
| HDAC1 | 6 | SYNPO | 6545 | TUBB3 | 5 | PRKAR1B | 1300 | NR4A1 | 3 | ANXA1 | 54 |
| NDUFS2 | 6 | PPP1R12B | 6084 | APOA1 | 5 | PFKL | 1162 | HSF2 | 3 | ELMSAN1 | 54 |
| TTN | 6 | SIRT4 | 5093 | PLEC | 5 | MYO19 | 1095 | FASN | 3 | STOM | 54 |
The top twenty hub and bottleneck genes are also provided for the sub-network that was unique to the Exercise Response (i.e. constructed from genes differentially expressed in response to exercise but not training)