Table 3.
The top twenty hub (based on node degree, D) and bottleneck (based on node betweenness, B) genes in the Exercise Response network in the Untrained Rest (UR) and Trained Exercise (TR) states
| Untrained Rest | Trained Rest | Unique to Trained Rest | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hubs | D | Bottlenecks | B | Hubs | D | Bottlenecks | B | Hubs | D | Bottlenecks | B |
| NDUFA6 | 20 | GABARAPL1 | 819 | NDUFA6 | 19 | GABARAPL1 | 2137 | KDR | 3 | MAPK10 | 6 |
| GABARAPL1 | 19 | NDUFA4 | 459 | GABARAPL1 | 15 | ATP5C1 | 1631 | TUBA1A | 3 | ARRB1 | 6 |
| NDUFA2 | 15 | NDUFA6 | 432 | NDUFA2 | 14 | SPTBN1 | 1135 | NCOA4 | 2 | KDR | 5 |
| ATP5F1 | 8 | NDUFA2 | 320 | ATP5F1 | 8 | NDUFB3 | 1067 | NIN | 2 | JUN | 4 |
| GRB2 | 7 | GRB2 | 177 | SPTBN1 | 5 | PRDX2 | 935 | JUN | 2 | APP | 4 |
| CDC37 | 6 | MYO18A | 158 | ACAD9 | 5 | NDUFA2 | 933 | MAPK10 | 2 | NCOA4 | 3 |
| ACAD9 | 6 | ATP5F1 | 125 | MYO19 | 5 | SYNPO | 842 | ARRB1 | 2 | TUBA1A | 3 |
| NCK1 | 6 | NDUFV3 | 98 | MYO18A | 5 | A2M | 814 | APP | 2 | NIN | 1 |
| TUBA1A | 5 | ATP5A1 | 88 | MAPK6 | 4 | NDUFA6 | 777 | RIPK4 | 2 | RIPK4 | 1 |
| MYO18A | 5 | ASB16 | 85 | ARAF | 4 | MYO18A | 608 | TNKS2 | 1 | TNKS2 | 0 |
| CACNA1A | 4 | ATP5B | 82 | LUZP1 | 4 | ARAF | 565 | IPO4 | 1 | IPO4 | 0 |
| ATP5B | 4 | NCK1 | 82 | KDR | 4 | MYO19 | 549 | EGLN3 | 1 | EGLN3 | 0 |
| HSF2BP | 4 | CAPZB | 78 | PRDX2 | 4 | APP | 509 | LUZP1 | 1 | LUZP1 | 0 |
| ATP5C1 | 4 | ACAD9 | 76 | PDLIM7 | 4 | ACAD9 | 401 | C1QB | 1 | C1QB | 0 |
| MAPK6 | 3 | ATP5J2 | 76 | SYNPO | 4 | ATP5F1 | 395 | C1QA | 1 | C1QA | 0 |
| EGLN3 | 3 | ATP5C1 | 72 | ATP5C1 | 4 | TPRN | 323 | SPRY1 | 1 | SPRY1 | 0 |
| HDAC1 | 3 | NDUFB3 | 64 | HDAC1 | 3 | PDLIM7 | 320 | FGF2 | 1 | FGF2 | 0 |
| CAPZB | 3 | PHYHIP | 50 | SPRY1 | 3 | ACADM | 320 | FGFBP1 | 1 | FGFBP1 | 0 |
| KDR | 3 | DLD | 50 | NDUFS2 | 3 | ARRB1 | 246 | CACNA1A | 1 | CACNA1A | 0 |
| NDUFA4 | 3 | PRDX2 | 50 | CDC37 | 3 | MYO1B | 246 | DYNLL1 | 1 | DYNLL1 | 0 |
The top twenty hub and bottleneck genes are also provided for the sub-network that was unique to the Training Response (i.e. constructed from genes differentially expressed in response to training but not exercise)