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. 2017 Aug 9;16:322. doi: 10.1186/s12936-017-1970-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effect of age on the relationship between sickle cell trait and malaria incidence. Using data from a longitudinal follow up of cohort children, the means (±standard deviation) of annual malaria episodes per child (incidence rates) for sickle cell HBB heterozygotes (Hb AS, cycle symbols) and wild types (Hb AA, rectangle symbols) over four age categories are presented. Children with wild type Hb (AA) experienced lower incidences in early infancy (till age of 1 year) than sickle cell HBB heterozygotes. Through ages >1–9 years, malaria incidences were largely similar