Table 3.
Effect of host genetic polymorphism on incidence of malaria
| Host polymorphism | Malaria | Number of new episodes | Adjusted incidence rate ratio | P value | 95% CI | |
|---|---|---|---|---|---|---|
| No | Yes | |||||
| G6PD c.202 G>A | ||||||
| Wild type | 166 | 161 | 318 | Reference | – | – |
| Heterozygous | 37 | 32 | 59 | 0.98 | 0.918 | 0.672–1.429 |
| Homozygous | 3 | 1 | 3 | 1.38 | 0.673 | 0.313–6.033 |
| Hemizygous | 11 | 12 | 34 | 1.60 | 0.081 | 0.944–2.698 |
| Homo/hemizygous | 14 | 13 | 37 | 1.57 | 0.076 | 0.954–2.590 |
| HBB c.20 A>T | ||||||
| Wild type | 158 | 145 | 289 | Reference | – | – |
| Heterozygous | 57 | 53 | 110 | 1.04 | 0.818 | 0.755–1.427 |
| NOS2 −954 G>C | ||||||
| Wild type | 169 | 171 | 358 | Reference | – | – |
| Heterozygous | 40 | 26 | 41 | 0.59 | 0.012 | 0.386–0.887 |
| Homozygous | 2 | 3 | 5 | 1.29 | 0.683 | 0.383–4.333 |
Only one child was homozygous for HBB c.20A>T variant and was not included in this analysis