Skip to main content
. Author manuscript; available in PMC: 2017 Aug 10.
Published in final edited form as: J Immunol. 2008 Dec 15;181(12):8552–8558. doi: 10.4049/jimmunol.181.12.8552

FIGURE 1.

FIGURE 1

Self-cured infection induced a protective immunity against blood stages but not against liver parasites. Groups of BALB/c mice were i.v. injected with 4000 P. yoelii 265BY sporozoite. All mice develop patent self-limiting blood parasitemia that cured by day 20. The mice were then rested for 15 days before challenge. A, Sterile protection in self-cured mice. Self-cured naive mice were challenged with 4000 homologous sporozoites. All naive mice (n = 5) developed patent blood stage parasitemia after sporozoite challenge. A mouse was considered protected if it did not develop patent blood stage parasitemia by day 10 after sporozoite challenge. Significant difference (p < 0.01) between self-cured naive mice was determined by Fisher’s exact test. B, Groups of naive BALB/c mice were infected allowed to self-cure as in A before challenge with 35,000 live sporozoites, so that the extent of hepatic parasite development could be assessed (29). Results were expressed as mean liver parasite load in log units ± SEM of n = 5 mice.