Table II.
Role of B cells in the protection conferred by immunization with iRBC under chloroquine cover
| Mouse Strain | Immunogena | Infected/Injectedb | Protection (%) |
|---|---|---|---|
| WT | None | 5/5 | 0 |
| WT | Py17X-iRBC | 0/5 | 100 |
| BKO | None | 5/5 | 0c |
| BKO | Py17X-iRBC | 3/3 | 0c |
a
Wild-type (WT) BKO BALB/c mice were immunized with 106 P. yoelii 17XNL clone 1.1 iRBC (Py17X-iRBC) treated with daily doses of 0.8 mg of chloroquine from day 0 to 15.
b
Mice were challenged by i.v. injection with 4000 sporozoites.
c
p < 0.05 between immunized WT BKO mice determined by Fischer’s exact test at day 10 postchallenge.