Table 3. Common dose and fractionation schemes based on clinical scenario and prior overlapping RT doses.

Clinical Scenario	Reasonable Dose/Fractionation Schedules
No prior RT, single vertebral level, no epidural disease	16–24 Gy × 1 fraction
	12 Gy × 2 fractions
	8–10 Gy × 3 fractions
No prior RT, multiple vertebral levels &/or epidural disease	16–18 Gy × 1 fraction
	12 Gy × 2 fractions
	8–10 Gy × 3 fraction
	6–8 Gy × 5 fractions
No prior RT, epidural disease	16–18 Gy × 1 fraction
	12 Gy × 2 fractions
	8 Gy × 4 fractions
	6–7 Gy × 5 fractions
Prior RT, any extent of epidural disease	16–18 Gy × 1 fraction
	12 Gy × 2 fractions
	7–10 Gy × 3 fractions
	8–10 Gy × 4 fractions
	5–7 Gy × 5 fractions