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. Author manuscript; available in PMC: 2017 Aug 10.
Published in final edited form as: Virology. 2016 Apr 20;494:89–99. doi: 10.1016/j.virol.2016.04.013

Figure 6. Residue 190 and 400 of PA affect virulence of an avian H7N3 influenza virus.

Figure 6

H7N3 viruses were generated containing single point mutations at position 184 (N184S), 190 (P190S), and 400 (Q400P) of the H7N3 PA polymerase gene. Female DBA/2J mice were infected with 102 TCID50 of H7N3 viruses containing each of the four point mutations and mortality (A) and morbidity (B) was compared to H7N3 and H7N3 PAN9 virus. Each virus strain was tested in two or more separate experiments and includes at least eight animals per strain of IAV. ** = P<0.01; *** = P<0.001.