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. Author manuscript; available in PMC: 2017 Aug 10.
Published in final edited form as: Virology. 2016 Apr 20;494:89–99. doi: 10.1016/j.virol.2016.04.013

Table 1.

Morbidity and mortality in DBA/2 mice after inoculation with mutant or reassortant avian H7 influenza viruses.

Virus Dose1 N % Mortality % Weight-loss on d8 (SEM)
H7N3-wt& 103 4 100 26.8 (0.4)
H7N3-rg 103 15 100 29.0 (0.7)
H7N3-5+3# 103 8 63 20.8 (1.5)
H7N3-6+2 103 8 100 23.5 (1.1)
H7N3-7+1 103 9 100 27.7 (0.9)
H7N9-wt 103 5 20 7.2 (3.5)
H7N9-rg 103 13 15 7.0 (2.6)
H7N9-5+3 103 8 75 25.1 (1.4)
H7N9-6+2 103 8 62 16.6 (2.5)
H7N9-7+1 103 7 29 15.0 (2.4)
H7N9 PB2V358E 103 15 33 15.9 (1.5)
H7N3-rg 102 40 83 23.9 (1.1)
H7N3-5+3 102 8 0 -0.6 (2.9)
H7N3 PB2N9 102 33 37 12.0 (2.5)
H7N3 PB2G62R 102 10 90 23.0 (1.1)
H7N3 PB2E358V 102 10 20 15.3 (2.4)
H7N3 PB2A471T 102 10 100 29.9 (0.7)
H7N3 PB2E681G 102 10 90 24.4 (1.7)
H7N3 PB1N9 102 7 86 15.8 (1.2)
H7N3 PAN9 102 17 12 5.8 (2.8)
H7N3 PAN184S 102 10 90 23.3 (0.8)
H7N3 PAP190S 102 9 44 13.6 (2.4)
H7N3 PAQ400P 102 10 50 9.8 (3.7)
H7N9-rg 102 4 0 -7.0 (2.4)
H7N9-5+3 102 4 50 18.7 (2.4)
1

Dose in TCID50/30μl inoculum volume.

&

wt = wild-type virus, rg = reverse genetics or plasmid-derived virus.

#

H7N3 5+3 denotes H7N3 influenza A virus genetic backbone with the PB2, PB1 and PA of H7N9 virus. Similarly 6+2, and 7+1 denotes a reassortment of the HA and NA, or NS gene-segment respectively.