Table 1.
Morbidity and mortality in DBA/2 mice after inoculation with mutant or reassortant avian H7 influenza viruses.
| Virus | Dose1 | N | % Mortality | % Weight-loss on d8 (SEM) |
|---|---|---|---|---|
| H7N3-wt& | 103 | 4 | 100 | 26.8 (0.4) |
| H7N3-rg | 103 | 15 | 100 | 29.0 (0.7) |
| H7N3-5+3# | 103 | 8 | 63 | 20.8 (1.5) |
| H7N3-6+2 | 103 | 8 | 100 | 23.5 (1.1) |
| H7N3-7+1 | 103 | 9 | 100 | 27.7 (0.9) |
| H7N9-wt | 103 | 5 | 20 | 7.2 (3.5) |
| H7N9-rg | 103 | 13 | 15 | 7.0 (2.6) |
| H7N9-5+3 | 103 | 8 | 75 | 25.1 (1.4) |
| H7N9-6+2 | 103 | 8 | 62 | 16.6 (2.5) |
| H7N9-7+1 | 103 | 7 | 29 | 15.0 (2.4) |
| H7N9 PB2V358E | 103 | 15 | 33 | 15.9 (1.5) |
| H7N3-rg | 102 | 40 | 83 | 23.9 (1.1) |
| H7N3-5+3 | 102 | 8 | 0 | -0.6 (2.9) |
| H7N3 PB2N9 | 102 | 33 | 37 | 12.0 (2.5) |
| H7N3 PB2G62R | 102 | 10 | 90 | 23.0 (1.1) |
| H7N3 PB2E358V | 102 | 10 | 20 | 15.3 (2.4) |
| H7N3 PB2A471T | 102 | 10 | 100 | 29.9 (0.7) |
| H7N3 PB2E681G | 102 | 10 | 90 | 24.4 (1.7) |
| H7N3 PB1N9 | 102 | 7 | 86 | 15.8 (1.2) |
| H7N3 PAN9 | 102 | 17 | 12 | 5.8 (2.8) |
| H7N3 PAN184S | 102 | 10 | 90 | 23.3 (0.8) |
| H7N3 PAP190S | 102 | 9 | 44 | 13.6 (2.4) |
| H7N3 PAQ400P | 102 | 10 | 50 | 9.8 (3.7) |
| H7N9-rg | 102 | 4 | 0 | -7.0 (2.4) |
| H7N9-5+3 | 102 | 4 | 50 | 18.7 (2.4) |
1
Dose in TCID50/30μl inoculum volume.
&
wt = wild-type virus, rg = reverse genetics or plasmid-derived virus.
#
H7N3 5+3 denotes H7N3 influenza A virus genetic backbone with the PB2, PB1 and PA of H7N9 virus. Similarly 6+2, and 7+1 denotes a reassortment of the HA and NA, or NS gene-segment respectively.