Table 3.
Effects of PB2E358V and PAP190S substitutions on virus replication in vivo.
| Virus | Lung virus titer (log10/ml) | |||
|---|---|---|---|---|
|
| ||||
| Day 2 | Day 3 | Day 6 | Day 9 | |
| H7N3 | 3.9 (0.6) | 5.4 (0.7) | 6.0 (0.8) | 5.9 (0.5) |
| H7N3 PB2E358V | 2.2 (0.5)*** | 4.9 (1.0) | 6.2 (0.5) | 4.4 (1.2)** |
| H7N3 PAP190S | 4.5 (1.0)* | 4.9 (1.1) | 5.6 (0.7) | ND |
Average lung virus titers in H7N3 or mutant virus infected DBA/2J animals. Results are the average and standard deviation of the log10-transformed virus titer obtained from at least two different experiments.
***
= P<0.001;
**
= P<0.01;
*
= P<0.05.
ND = not done.