Table 2.
Pharmacokinetics parameters t1/2, Cmax, AUC0–480, AUC0–∞, Tmax, CL, Vd, and MRT of M1 after the injection (SC) of F1, F2, F3, and F4 in rabbits. Data expressed as mean (±SD).
| F1 | F2 | F3 | F4 | |
|---|---|---|---|---|
| t1/2 (h) | 2.64 ± 0.86 | 4.55 ± 1.44 | 4.02 ± 2.48 | 5.57 ± 8.36 |
| Tmax (h) | 0.70 ± 0.27 | 2.70 ± 2.04 | 2.95 ± 2.70 | 1.58 ± 1.75 |
| Cmax (ng·mL−1) | 27.00 ± 2.69a∗∗ | 7.82 ± 2.23 | 15.17 ± 9.96 | 21.89 ± 11.81 |
| AUC0–480 (ng-h·L−1) | 89.28 ± 5.26 | 37.82 ± 11.93 | 56.18 ± 39.59 | 65.79 ± 50.29 |
| AUC0–∞ (ng-h·L−1) | 121.71 ± 34.00a∗ | 48.92 ± 6.31 | 109.06 ± 53.35 | 83.57 ± 53.82 |
| V d (L) | 310.97 ± 53.25a∗∗∗ | 1325.73 ± 320.55 | 611.87 ± 379.42 | 286.80 ± 96.56 |
| CL (L/h) | 86.71 ± 20.70 | 207.10 ± 26.48 | 120.02 ± 81.57 | 111.78 ± 48.61 |
| MRT (h) | 2.99 ± 0.26 | 3.71 ± 0.43 | 3.85 ± 1.23 | 3.02 ± 1.02 |
Statistical analysis: aF1 versus F2; p < 0.001 [∗∗∗], p < 0.01 [∗∗], and p < 0.05 [∗], ANOVA/Tukey-Kramer.