Table 5.

Estimated mean differences between treatments for differences from baseline for lesion area. Estimates of treatment contrasts were based on a hierarchical random effects model with random effects for tooth and specimen nested within tooth and fixed effects for treatment, time, and treatment*time interaction. Point estimates for treatment comparisons are given for each time point, along with 95% confidence intervals for the differences, unadjusted p-values, and p-values adjusting for multiple comparisons.

Treatment Comparison	Day	Estimate	95% CI	P-value	Adj P-value
F5000 vs Control	10	−3.29	(−4.19, −2.39)	<0.001	<0.001
F5000 vs Control	20	−2.93	(−3.87, −1.99)	<0.001	<0.001
F5000 vs Control	30	−1.69	(−2.75, −0.64)	0.002	0.008
F5000 vs MI Paste Plus	10	−2.07	(−2.97, −1.17)	<0.001	<0.001
F5000 vs MI Paste Plus	20	−1.73	(−2.68, −0.78)	<0.001	0.002
F5000 vs MI Paste Plus	30	−2.04	(−3.10, −0.99)	<0.001	0.001
F5000 vs MI Paste	10	−2.94	(−3.85, −2.04)	<0.001	<0.001
F5000 vs MI Paste	20	−3.28	(−4.24, −2.32)	<0.001	<0.001
F5000 vs MI Paste	30	−3.79	(−4.86, −2.71)	<0.001	<0.001
MI Paste Plus vs Control	10	−1.22	(−2.12, −0.32)	0.007	0.04
MI Paste Plus vs Control	20	−1.2	(−2.15, −0.26)	0.01	0.05
MI Paste Plus vs Control	30	0.35	(−0.70, 1.41)	0.51	1.0
MI Paste vs Control	10	−0.35	(−1.25, 0.56)	0.45	1.0
MI Paste vs Control	20	0.34	(−0.61, 1.30)	0.48	1.0
MI Paste vs Control	30	2.09	(1.02, 3.17)	<0.001	0.001
MI Paste Plus vs MI Paste	10	−0.87	(−1.78, 0.03)	0.06	0.24
MI Paste Plus vs MI Paste	20	−1.55	(−2.51, −0.59)	0.001	0.008
MI Paste Plus vs MI Paste	30	−1.74	(−2.82, −0.67)	0.001	0.008