Table 5.
Drug content analysis for the compatibility study of F1 b (10% LNS- 30% F68- K12) and F2 (10% LNS- 4% MgO- 30% F68- K12) mixed with the enteric coating polymer L100-55 in a ratio of 1:2 after 6 and 12 months of storage (25°C/60% RH)
Mixture | Duration of the sorage (months) | Drug content (%) |
---|---|---|
F1 b + Eudragit® L100-55 | 6 | 9.3 ± 1.2 |
F1 b + Eudragit® L100-55 | 12 | 0 |
F2 + Eudragit® L100-55 | 6 | 97 ± 2.3 |
F2 + Eudragit® L100-55 | 12 | 97 ± 5.1 |
(mean ± SD, n = 3)