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. Author manuscript; available in PMC: 2017 Aug 10.
Published in final edited form as: J Reward Defic Syndr Addict Sci. 2017 Apr 28;3(1):3–13.

Figure 5.

Figure 5

Resting-state fMRI one hour after one dose of KB220 variant.

Left side placebo (n=5)

Right side KB220 variant (n=5)

It represents a fMRI cross-over study in five abstinent heroin addicts receiving either placebo or KB220Z (Synaptose) one –hour prior to testing. It is noteworthy, that following oral KB220Z there is BOLD activation in the NAc and a attenuation of high BOLD activation in the putamen. This illustration suggests a balancing of dopamine function in the brain at the reward site [63] (with permission).