. Author manuscript; available in PMC: 2017 Aug 10.

Published in final edited form as: Nat Rev Rheumatol. 2015 Mar 24;11(5):301–312. doi: 10.1038/nrrheum.2015.29

Table 3.

Affect of maternal autoimmune disease on risk of CHB—pooled analysis of prospective studies

Maternal diagnosis	Incidence of CHB^{19,22,28,62,82,83}			Recurrence of CHB^{19,36,40,63,83}

	Ro⁺ mothers (n)	Total CHB (n)	Type of CHB among Ro⁺ mothers	Ro⁺ mothers with previous CHB (n)^‡	Recurrence of CHB (n)	Type of CHB specified among Ro⁺ mothers
SLE	303^*	3 (1%)	NS	13^*	3 (23.1%)	Type III (n =2) NS (n =1)

pSS	104^*	3 (2.9%)	Type II (n =1) Type III (n =2)	31^*	7 (22.6%)	Type III (n =6) NS (n =1)

Undifferentiated autoimmune diseases	87	2 (2.3%)	Type III (n =2)	13	1 (7.7%)	Type III (n =1)

Asymptomatic Ro/La⁺	25	2 (8%)	NS	24	3 (12.5%)	Type III (n =2) NS (n =1)

Other autoimmune diseases	11	0 (0%)	None	3	1 (33%)	Type III (n =1)

5 mothers had both pSS and SLE, so were included in both groups.

^‡

17 Ro⁺ mothers (6 with SLE, 3 with pSS, 1 with MCTD, 6 asymptomatic and 1 with Raynaud phenomenon) had a previous history of NLE.

Abbreviations: CHB, congenital heart block; NS, not specified; pSS, primary Sjögren syndrome; SLE, systemic lupus erythematosus.