Table 4.
Recurrence of CHB in Ro+ mothers with a previous history of CHB
| Study (year) | Inclusion criteria (type of CHB) | Ro+ mothers (n=317) | Babies (n=326) | CHB (n=50) | Types of CHB |
|---|---|---|---|---|---|
| Gladman et al.83 (2002) | Previous type III CHB | 11 | 12 | 1 (9%) | Type III (n =1, 9%) |
| Cimaz et al.19 (2003) | Previous NLE (13 type III CHB, 4 CNLE) | 17* | 17 | 2 (11.76%) | Type III (n =2, 11.76%) |
| Costedoat et al.22 (2004) | Previous CHB (ND) | 7 | 13 | 0 | None |
| Friedman et al.62 (2008) | Previous CHB (ND) | 16 | 16 | 3 (18.75%) | Type I (n =2, 12.5%) Type III (n =1, 6.25%) |
| Buyon et al.68 (1998) | Previous CHB (ND) | 49 | 49 | 8 (16.32%) | ND |
| Julkunen et al.89 (2001) | Previous CHB (ND) | 47 | 47 | 8 (17.02%) | Type I (ND)‡ Type II (n =1, 2.12%) Type III (n =7, 14.89%) |
| Kaaja et al.36 (2003) | Previous CHB (ND) | 8 | 8 | 1 (12.50%) | ND |
| Solomon et al.90 (2003) | Previous type I, II or III CHB | 87 | 87 | 16 (18.39%) | Type I (n =4, 4.59%) Type II or III (n =12, 13.79%) |
| Friedman et al.63 (2010) | Previous type I, II or III CHB | 20* | 20 | 3 (15.00%) | Type III (n =3, 15.00%) |
| Pisoni et al.40 (2010) | Previous type III CHB | 22 | 24 | 4 (18.18%) | Type III (n =4, 18.18%) |
| Ambrosi et al.86 (2012) | Previous CHB (ND) | 33 | 33 | 4 (12.12%) | ND |
| Totals | NA | 317 | 326 | 50 (15.8%) | Type I (n = 6 of 180, 2.54%) Types II or III (n = 12 of 87, 13.79%) Type II (n = 1 of 140, 0.71%) Type III (n = 18 of 140, 12.86%) |
*
Previous history of NLE (6 cases with isolated cutaneous involvement were also included).
‡
Type I CHB was not included in this study.
Abbreviations: CHB, congenital heart block; CNLE, cutaneous neonatal lupus erythematosus; NA, not applicable; ND, not detailed; NLE, neonatal lupus erythematosus.